Simon McGrath: PACE trial shows why medicine needs patients to scrutinise studies about their health

Like all patients, what I want most from clinical research is treatments that work, not ones that merely look good on paper. As The BMJ has pointed out, patients are often faced with over-hyped treatments and an incomplete research base biased towards positive results. These biases arise partly because of “publish or perish” pressure on […]

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Ian R Barker: Compassion fatigue—the neglected problem

Compassion fatigue—also known as vicarious traumatisation results in a gradual reduction in compassion over time. It is more common in those dealing with trauma or caring for close relatives (1). If often presents as hopelessness, decrease in experience of pleasure, constant stress and anxiety, and a pervasive negative attitude (2). Interestingly, it has been claimed […]

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Clara Hellner Gumpert: The Karolinska Institute after the Macchiarini scandal

In 2010, Paolo Macchiarini, an Italian doctor and researcher, was recruited as a guest professor to the Karolinska Institute, and as a surgeon to the Karolinska University Hospital. In 2008, Macchiarini performed the first transplant of a trachea from a dead donor. Prior to the transplant, the trachea was prepared with stem cells. Between 2011 […]

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Richard Lehman: Where next with statins?

The Lancet‘s lengthy review on statins is masterly in its discussion of many fundamental issues about trial methodology and interpretation, and makes an excellent case for the overall benefits of statins for cardiovascular protection. But this is not new news. The discussion of adverse effects is theoretically sound but offers no new data and does […]

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Julian Tudor Hart: Government, healthcare professionals, and the people’s NHS: time for a new hypothesis?

Until the BMA rejected the government’s contract imposed on junior doctors in NHS England, negotiations were conducted in conventional diplomatic terms, based on a shared hypothesis that all contestants played an open hand, meant what they said, without covert motives. 58% of junior doctors have now indicated that they are no longer willing even to […]

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