The BMJ Today: Prescribing on sparse evidence, homeopathy, and research methodology

How to prescribe when the evidence is lacking • Several observational studies have shown associations between using drugs with anticholinergic side effects—such as loperamide, loratadine, baclofen, amitriptyline, oxybutynin, or chlorphenamine—and cognitive decline. Links have also been shown with earlier death, falls, and admission to hospital with confusion and dementia. “But is this cause, or is […]

Read More…

The BMJ Today: Treatments for inflammatory diseases

A combination of old drugs is not inferior to biologics for rheumatoid arthritis • Tumor necrosis factor inhibitors are safe and effective therapies for patients with rheumatoid arthritis resistant to methotrexate and other disease modifying drugs, but they are very expensive. The BMJ Today reports the results of an open label pragmatic trial—the TACIT trial—that […]

Read More…

BMJ Today: Reassurance on varenicline, caring (or not) for NHS staff, and more holiday for emergency doctors

Good news for quitters A research paper in The BMJ today “is the most comprehensive published review to date of the neuropsychiatric safety of varenicline.” It was necessary, say the authors from Bristol University, because while several studies have found no evidence of an increased risk of neuropsychiatric side effects with varenicline, these studies have […]

Read More…