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<\/p>\n","protected":false},"excerpt":{"rendered":"Amyotrophic lateral sclerosis (ALS) was traditionally regarded as a disorder of only the motor neurons and their connections to the brain.\u00a0 Although Charcot, who described and coined the term ALS, proposed a central origin of ALS, is was Professor Andrew Eisen who set the cats amongst the pigeons by suggesting that ALS was primarily a disorder of the upper motor neurons, with motor neuron degeneration being a secondary event.\u00a0 The discovery of the c9orf72 gene as a major genetic cause of ALS underscored Professor Eisens’ hypothesis, although other supportive evidence has also been reported.<\/p>\n
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In an upcoming issue Chio’s group re-affirms that importance of cognitive\u00a0 dysfunction in a population based study of Italian ALS patients.\u00a0 Importantly these findings corroborate earlier studies , and have clear pathophysiological and potential therapeutic implications for ALS.<\/p>\n
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Read more at http:\/\/jnnp.bmj.com\/content\/early\/2014\/04\/25\/jnnp-2013-307223.short?g=w_jnnp_ahead_tab<\/p>\n
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Amyotrophic lateral sclerosis (ALS) was traditionally regarded as a disorder of only the motor neurons and their connections to the brain.\u00a0 Although Charcot, who described and coined the term ALS, proposed a central origin of ALS, is was Professor Andrew Eisen who set the cats amongst the pigeons by suggesting that ALS was primarily a […]<\/p>\n