The detection of autoantibodies in autoimmune CNS disorders has been if immense interest, with implications for undelrying pathophysiology.\u00a0 A variety of autoantibodies have been detected and associated with various CNS syndromes, although the question remians whether these antibodies are pathogenic, an epiphenomenon, or both.<\/p>\n
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In this issue of JNNP, Hacohen and colleagues report on antibody biomakers in CNS demyelinating disorders of childhood.\u00a0 A variety of anibodies and syndromew were reported, with the bottom line being that specific antibodies are associated with specific syndromes.\u00a0 Consequently, the principles of good medical practice remians to define the phenotype and then look for the “genotype” or in thid case the antibody.\u00a0 In addition, the relevance of antibodies in the underlying pathophysiology needs further research.<\/p>\n
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Do you think it is worthwhile looking for these antibodies?\u00a0 let me know your thoughrs via twitter.<\/p>\n
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Read more at http:\/\/jnnp.bmj.com\/content\/85\/4\/456\/T1.expansion.html<\/p>\n
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The detection of autoantibodies in autoimmune CNS disorders has been if immense interest, with implications for undelrying pathophysiology.\u00a0 A variety of autoantibodies have been detected and associated with various CNS syndromes, although the question remians whether these antibodies are pathogenic, an epiphenomenon, or both. In this issue of JNNP, Hacohen and colleagues report on […]<\/p>\n