{"id":983,"date":"2017-03-13T19:21:00","date_gmt":"2017-03-13T19:21:00","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=983"},"modified":"2017-03-13T19:21:00","modified_gmt":"2017-03-13T19:21:00","slug":"multiple-signals-at-the-extended-8p23-locus-are-associated-with-susceptibility-to-systemic-lupus-erythematosus","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2017\/03\/13\/multiple-signals-at-the-extended-8p23-locus-are-associated-with-susceptibility-to-systemic-lupus-erythematosus\/","title":{"rendered":"Multiple signals at the extended 8p23 locus are associated with susceptibility to systemic lupus erythematosus"},"content":{"rendered":"<p>One of the major susceptibility loci identified for Systemic lupus erythematosus (SLE) lies within a common large inversion polymorphism region on chromosome 8p23. In this study, we further investigated the \u2018extended\u2019 8p23 locus (~4 Mb) where we observed multiple SLE signals and assessed these signals for their relation to the inversion affecting this region. The study involved a North American discovery dataset (<em>~<\/em>1,200 subjects) and a replication dataset (&gt;10,000 subjects) comprising European-descent individuals. Our results have implicated multiple (known+novel) SLE signals\/genes at the extended 8p23 locus and suggested that this broad locus contributes to SLE risk through the effects of multiple genes\/pathways. Our findings underline the importance of evaluating the entire inversion region for any disease\/trait linked to this 8p23 locus. (By Dr. F. Yesim Demirci, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2017\/03\/13\/jmedgenet-2016-104247\">http:\/\/jmg.bmj.com\/content\/early\/2017\/03\/13\/jmedgenet-2016-104247<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>One of the major susceptibility loci identified for Systemic lupus erythematosus (SLE) lies within a common large inversion polymorphism region on chromosome 8p23. In this study, we further investigated the \u2018extended\u2019 8p23 locus (~4 Mb) where we observed multiple SLE signals and assessed these signals for their relation to the inversion affecting this region. The [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2017\/03\/13\/multiple-signals-at-the-extended-8p23-locus-are-associated-with-susceptibility-to-systemic-lupus-erythematosus\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-983","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/983","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=983"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/983\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=983"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=983"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=983"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}