{"id":910,"date":"2016-07-28T19:00:43","date_gmt":"2016-07-28T19:00:43","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=910"},"modified":"2016-07-28T19:00:43","modified_gmt":"2016-07-28T19:00:43","slug":"new-insights-in-the-molecular-signature-of-advanced-medullary-thyroid-cancer-evidence-of-a-bad-outcome-of-cases-with-double-ret-mutations","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2016\/07\/28\/new-insights-in-the-molecular-signature-of-advanced-medullary-thyroid-cancer-evidence-of-a-bad-outcome-of-cases-with-double-ret-mutations\/","title":{"rendered":"New insights in the molecular signature of advanced medullary thyroid cancer: evidence of a bad outcome of cases with double RET mutations"},"content":{"rendered":"<p>Advanced sporadic MTC are characterized by a high prevalence of <em>RET<\/em> somatic mutations. In particular the M918T is the most frequent mutation but also small deletions\/insertions (complex mutations can be present. In some cases more than one <em>RET<\/em> mutation can occur. <em>K-<\/em> or <em>H-RAS<\/em> mutations are also present even if at a lower frequency. <em>RET<\/em> and <em>RAS<\/em> mutations are mutually exclusive. Cases with multiple or complex mutations have a worse outcome. (By Drs. Rossella Elisei and Cristina Romei, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2016\/07\/28\/jmedgenet-2016-103833\">http:\/\/jmg.bmj.com\/content\/early\/2016\/07\/28\/jmedgenet-2016-103833<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Advanced sporadic MTC are characterized by a high prevalence of RET somatic mutations. In particular the M918T is the most frequent mutation but also small deletions\/insertions (complex mutations can be present. In some cases more than one RET mutation can occur. K- or H-RAS mutations are also present even if at a lower frequency. RET [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2016\/07\/28\/new-insights-in-the-molecular-signature-of-advanced-medullary-thyroid-cancer-evidence-of-a-bad-outcome-of-cases-with-double-ret-mutations\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-910","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/910","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=910"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/910\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=910"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=910"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=910"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}