{"id":885,"date":"2016-04-26T18:36:06","date_gmt":"2016-04-26T18:36:06","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=885"},"modified":"2016-04-26T18:36:06","modified_gmt":"2016-04-26T18:36:06","slug":"when-chromatin-organisation-floats-astray-the-srcap-gene-and-floating-harbor-syndrome","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2016\/04\/26\/when-chromatin-organisation-floats-astray-the-srcap-gene-and-floating-harbor-syndrome\/","title":{"rendered":"When chromatin organisation floats astray: the Srcap gene and Floating\u2013Harbor syndrome"},"content":{"rendered":"<p>Floating-Harbor syndrome (FHS) is a rare human disease characterized by developmental defects, often associated with mental retardation. FHS was first described at Boston\u2019s Floating Hospital in 1973, but the causative gene, called <em>Srcap<\/em>, was identified only recently. <em>Srcap<\/em> encodes a protein with a key role in control of gene expression, however, the underlying molecular bases of FHS still need elucidating.\u00a0In this review article, the authors critically examine recent studies on FHS, proposing possible mechanisms for the molecular events leading to the onset of the disease. \u00a0(By Professor Patrizio Dimitri, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2016\/04\/26\/jmedgenet-2016-103842\">http:\/\/jmg.bmj.com\/content\/early\/2016\/04\/26\/jmedgenet-2016-103842<\/a> )<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/stg-blogs.bmj.com\/jmg\/files\/2016\/04\/FHS-research-group.jpg\" rel=\"attachment wp-att-886\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-886\" src=\"https:\/\/stg-blogs.bmj.com\/jmg\/files\/2016\/04\/FHS-research-group-300x212.jpg\" alt=\"FHS research group\" width=\"300\" height=\"212\" srcset=\"https:\/\/stg-blogs.bmj.com\/jmg\/files\/2016\/04\/FHS-research-group-300x212.jpg 300w, https:\/\/stg-blogs.bmj.com\/jmg\/files\/2016\/04\/FHS-research-group-768x542.jpg 768w, https:\/\/stg-blogs.bmj.com\/jmg\/files\/2016\/04\/FHS-research-group-1024x723.jpg 1024w, https:\/\/stg-blogs.bmj.com\/jmg\/files\/2016\/04\/FHS-research-group.jpg 1181w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>From left to right:<br \/>\nMaria Teresa Atterrato, Giovanni Messina, Emanuele Celauro, Patrizio Dimitri, Yuri Prozzillo.<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Floating-Harbor syndrome (FHS) is a rare human disease characterized by developmental defects, often associated with mental retardation. FHS was first described at Boston\u2019s Floating Hospital in 1973, but the causative gene, called Srcap, was identified only recently. Srcap encodes a protein with a key role in control of gene expression, however, the underlying molecular bases [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2016\/04\/26\/when-chromatin-organisation-floats-astray-the-srcap-gene-and-floating-harbor-syndrome\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-885","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/885","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=885"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/885\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=885"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}