{"id":859,"date":"2016-02-01T21:19:45","date_gmt":"2016-02-01T21:19:45","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=859"},"modified":"2016-02-01T21:19:45","modified_gmt":"2016-02-01T21:19:45","slug":"hsp110-t17-simplifies-and-improves-the-microsatellite-instability-testing-in-patients-with-colorectal-cancer","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2016\/02\/01\/hsp110-t17-simplifies-and-improves-the-microsatellite-instability-testing-in-patients-with-colorectal-cancer\/","title":{"rendered":"HSP110 T17 simplifies and improves the microsatellite instability testing in patients with colorectal cancer"},"content":{"rendered":"<p>Every colorectal cancer (CRC) patient should be tested for Microsatellite Instability (MSI), as a first screen for Lynch syndrome (LS). Recently, clinical benefit from immune checkpoint blockade was reported in metastatic MSI CRCs. Hence, there is a high level of interest in studying the MSI phenotype as a potential prognostic and predictive biomarker in CRC patients. In the present work, we demonstrate that a new marker, HT17, simplifies and improves the current standard molecular methods for detecting MSI in colon tumor samples. We believe there is a strong rationale to use HT17 when screening for MSI in CRC. (By Ada Collura, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2016\/02\/01\/jmedgenet-2015-103518\">http:\/\/jmg.bmj.com\/content\/early\/2016\/02\/01\/jmedgenet-2015-103518<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Every colorectal cancer (CRC) patient should be tested for Microsatellite Instability (MSI), as a first screen for Lynch syndrome (LS). Recently, clinical benefit from immune checkpoint blockade was reported in metastatic MSI CRCs. Hence, there is a high level of interest in studying the MSI phenotype as a potential prognostic and predictive biomarker in CRC [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2016\/02\/01\/hsp110-t17-simplifies-and-improves-the-microsatellite-instability-testing-in-patients-with-colorectal-cancer\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-859","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/859","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=859"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/859\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=859"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=859"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=859"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}