{"id":772,"date":"2015-06-22T19:05:03","date_gmt":"2015-06-22T19:05:03","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=772"},"modified":"2015-06-22T19:05:03","modified_gmt":"2015-06-22T19:05:03","slug":"continued-lessons-from-the-ins-gene-an-intronic-mutation-causing-diabetes-through-a-novel-mechanism","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2015\/06\/22\/continued-lessons-from-the-ins-gene-an-intronic-mutation-causing-diabetes-through-a-novel-mechanism\/","title":{"rendered":"Continued lessons from the INS gene: an intronic mutation causing diabetes through a novel mechanism"},"content":{"rendered":"<p>Neonatal diabetes (diagnosed under 6 months of age) is usually caused by a disruption (mutation) in one of over twenty diabetes-related genes. One of the most common causes of neonatal diabetes is mutations in the insulin gene that result in production of a misshaped insulin protein that leads to death of the insulin producing beta cells. We describe a new type of mutation, deep in the non-coding part of the insulin gene, that causes diabetes through a previously undescribed mechanism. This discovery extends our understanding of diabetes and may have broader implications for those with insulin deficiency later in life. (By Dr. David Carmody, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2015\/06\/21\/jmedgenet-2015-103220\">http:\/\/jmg.bmj.com\/content\/early\/2015\/06\/21\/jmedgenet-2015-103220<\/a> )<\/p>\n<p><a href=\"https:\/\/stg-blogs.bmj.com\/jmg\/files\/2015\/06\/2B-revised-Tiff.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-773\" src=\"https:\/\/stg-blogs.bmj.com\/jmg\/files\/2015\/06\/2B-revised-Tiff-300x200.jpg\" alt=\"2B revised Tiff\" width=\"300\" height=\"200\" srcset=\"https:\/\/stg-blogs.bmj.com\/jmg\/files\/2015\/06\/2B-revised-Tiff-300x200.jpg 300w, https:\/\/stg-blogs.bmj.com\/jmg\/files\/2015\/06\/2B-revised-Tiff.jpg 945w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neonatal diabetes (diagnosed under 6 months of age) is usually caused by a disruption (mutation) in one of over twenty diabetes-related genes. One of the most common causes of neonatal diabetes is mutations in the insulin gene that result in production of a misshaped insulin protein that leads to death of the insulin producing beta [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2015\/06\/22\/continued-lessons-from-the-ins-gene-an-intronic-mutation-causing-diabetes-through-a-novel-mechanism\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-772","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/772","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=772"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/772\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=772"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=772"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=772"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}