{"id":760,"date":"2015-05-29T19:06:55","date_gmt":"2015-05-29T19:06:55","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=760"},"modified":"2015-05-29T19:06:55","modified_gmt":"2015-05-29T19:06:55","slug":"contribution-of-the-low-frequency-loss-of-function-p-r270h-mutation-in-ffar4-gpr120-to-increased-fasting-plasma-glucose-levels","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2015\/05\/29\/contribution-of-the-low-frequency-loss-of-function-p-r270h-mutation-in-ffar4-gpr120-to-increased-fasting-plasma-glucose-levels\/","title":{"rendered":"Contribution of the low-frequency, loss-of-function p.R270H mutation in FFAR4 (GPR120) to increased fasting plasma glucose levels"},"content":{"rendered":"<p>Mice deficient for the lipid sensor Gpr120 develop obesity and both impaired fasting glucose and glucose intolerance under a high-fat diet.<\/p>\n<p>In humans, a loss-of-function mutation in \/GPR120\/ was shown to markedly contribute to obesity. Here, the authors investigate the effect of the same mutation in type 2 diabetes and glucose-related traits. They identified a significant contribution of the mutation to increased fasting glucose levels and reduced pancreatic beta-cell function in<\/p>\n<p>9,000 non-diabetic participants of French-European origin. This study tends to confirm a potential role of GPR120 in pancreatic islets in humans (besides gut and adipose tissue). (By Dr. Am\u00e9lie Bonnefond, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2015\/05\/29\/jmedgenet-2015-103065\">http:\/\/jmg.bmj.com\/content\/early\/2015\/05\/29\/jmedgenet-2015-103065<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mice deficient for the lipid sensor Gpr120 develop obesity and both impaired fasting glucose and glucose intolerance under a high-fat diet. In humans, a loss-of-function mutation in \/GPR120\/ was shown to markedly contribute to obesity. Here, the authors investigate the effect of the same mutation in type 2 diabetes and glucose-related traits. They identified a [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2015\/05\/29\/contribution-of-the-low-frequency-loss-of-function-p-r270h-mutation-in-ffar4-gpr120-to-increased-fasting-plasma-glucose-levels\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-760","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/760","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=760"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/760\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=760"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=760"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}