{"id":66,"date":"2010-11-20T20:30:42","date_gmt":"2010-11-20T20:30:42","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=66"},"modified":"2010-11-20T20:30:42","modified_gmt":"2010-11-20T20:30:42","slug":"cancer-and-neurologic-degeneration-in-xeroderma-pigmentosum-long-term-follow-up-characterises-the-role-of-dna-repair","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2010\/11\/20\/cancer-and-neurologic-degeneration-in-xeroderma-pigmentosum-long-term-follow-up-characterises-the-role-of-dna-repair\/","title":{"rendered":"Cancer and neurologic degeneration in xeroderma pigmentosum: long term follow-up characterises the role of DNA repair"},"content":{"rendered":"<p>Xeroderma pigmentosum (XP) is a rare, inherited disorder of defective DNA repair, which can offer insights into the mechanism of cancer development and neurologic degeneration.<\/p>\n<p>This long-term study of 106 XP patients at the National Institutes of Health found a 10,000-fold increase in non-melanoma skin cancer (NMSC) and a 2,000-fold increase in melanoma following sun exposure. The NMSC occurred at a younger age than melanomas in XP patients. This age of onset is the reverse of what occurs in the general population, suggesting differences in carcinogenic mechanisms between melanoma and NMSC.<\/p>\n<p>Many XP patients have progressive neurologic degeneration, and a surprisingly high mortality, possibly due to unrepaired DNA damage from other agents. (By Dr. Kenneth H. Kraemer, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2010\/11\/19\/jmg.2010.083022.abstract?papetoc\">http:\/\/jmg.bmj.com\/content\/early\/2010\/11\/19\/jmg.2010.083022.abstract?papetoc<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Xeroderma pigmentosum (XP) is a rare, inherited disorder of defective DNA repair, which can offer insights into the mechanism of cancer development and neurologic degeneration. This long-term study of 106 XP patients at the National Institutes of Health found a 10,000-fold increase in non-melanoma skin cancer (NMSC) and a 2,000-fold increase in melanoma following sun [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2010\/11\/20\/cancer-and-neurologic-degeneration-in-xeroderma-pigmentosum-long-term-follow-up-characterises-the-role-of-dna-repair\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-66","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/66","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=66"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/66\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=66"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=66"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=66"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}