{"id":655,"date":"2014-04-29T18:54:49","date_gmt":"2014-04-29T18:54:49","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=655"},"modified":"2014-04-29T18:54:49","modified_gmt":"2014-04-29T18:54:49","slug":"prediction-of-the-age-at-onset-in-spinocerebellar-ataxia-type-1-2-3-and-6","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2014\/04\/29\/prediction-of-the-age-at-onset-in-spinocerebellar-ataxia-type-1-2-3-and-6\/","title":{"rendered":"Prediction of the age at onset in spinocerebellar ataxia type 1, 2, 3 and 6"},"content":{"rendered":"<p>The most common spinocerebellar ataxias (SCA), SCA1, SCA2, SCA3 and SCA6, are caused by a (CAG)n repeat expansion with a correlation between the number of repeats of the coding (CAG)n expansions and age at onset. We combined data from two major European cohorts of SCA1-3 and SCA6 carriers: affected individuals from the EUROSCA registry and pre-clinical individuals from the RISCA cohort. We calculated expected age at onset according to CAG repeat size from birth and from a given age to account for the age an individual has already attained. These estimations can be valuable in clinical, research and predictive-testing programs. (By Sophie T\u00e9zenas du Montcel, MD, PhD, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2014\/04\/29\/jmedgenet-2013-102200\">http:\/\/jmg.bmj.com\/content\/early\/2014\/04\/29\/jmedgenet-2013-102200<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The most common spinocerebellar ataxias (SCA), SCA1, SCA2, SCA3 and SCA6, are caused by a (CAG)n repeat expansion with a correlation between the number of repeats of the coding (CAG)n expansions and age at onset. We combined data from two major European cohorts of SCA1-3 and SCA6 carriers: affected individuals from the EUROSCA registry and [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2014\/04\/29\/prediction-of-the-age-at-onset-in-spinocerebellar-ataxia-type-1-2-3-and-6\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-655","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/655","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=655"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/655\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=655"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=655"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=655"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}