{"id":586,"date":"2013-09-24T01:45:11","date_gmt":"2013-09-24T01:45:11","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=586"},"modified":"2013-09-24T01:45:11","modified_gmt":"2013-09-24T01:45:11","slug":"genetic-variants-in-chi3l1-influencing-ykl-40-levels-resequencing-900-individuals-and-genotyping-9000-individuals-from-the-general-population","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2013\/09\/24\/genetic-variants-in-chi3l1-influencing-ykl-40-levels-resequencing-900-individuals-and-genotyping-9000-individuals-from-the-general-population\/","title":{"rendered":"Genetic variants in CHI3L1 influencing YKL-40 levels: resequencing 900 individuals and genotyping 9000 individuals from the general population"},"content":{"rendered":"<p>YKL-40, is a plasma protein mainly produced by inflammatory cells and cancer cells during tissue remodelling processes. Consequently, plasma YKL-40 levels are elevated in patients with diseases characterized by inflammation and cancer. Despite its role in many serious diseases, the genetic background for plasma YKL-40 still has not been systematically catalogued. In this study, we aimed to identify all genetic variants in <i>CHI3L1<\/i> influencing plasma YKL-40 levels. For this, we used extreme phenotype approach: From 8899 individuals from the general population with measured plasma YKL-40, we resequenced the gene in 10% of the individuals with extremely high or extremely low plasma YKL-40 levels. In total, we identified 59 genetic variants, of which 8 were associated with plasma YKL-40 levels (p&lt;10<sup>-8<\/sup>). This information might be valuable for future studies exploring the causal roles of YKL-40 for human health. (By Alisa D. Kjaergaard, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2013\/09\/23\/jmedgenet-2013-101908\">http:\/\/jmg.bmj.com\/content\/early\/2013\/09\/23\/jmedgenet-2013-101908<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>YKL-40, is a plasma protein mainly produced by inflammatory cells and cancer cells during tissue remodelling processes. Consequently, plasma YKL-40 levels are elevated in patients with diseases characterized by inflammation and cancer. Despite its role in many serious diseases, the genetic background for plasma YKL-40 still has not been systematically catalogued. In this study, we [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2013\/09\/24\/genetic-variants-in-chi3l1-influencing-ykl-40-levels-resequencing-900-individuals-and-genotyping-9000-individuals-from-the-general-population\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-586","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/586","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=586"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/586\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=586"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=586"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=586"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}