{"id":541,"date":"2013-06-04T19:04:04","date_gmt":"2013-06-04T19:04:04","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=541"},"modified":"2013-06-04T19:04:04","modified_gmt":"2013-06-04T19:04:04","slug":"identification-of-well-differentiated-gene-expressions-between-han-chinese-and-japanese-using-genome-wide-microarray-data-analysis","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2013\/06\/04\/identification-of-well-differentiated-gene-expressions-between-han-chinese-and-japanese-using-genome-wide-microarray-data-analysis\/","title":{"rendered":"Identification of well-differentiated gene expressions between Han Chinese and Japanese using genome-wide microarray data analysis"},"content":{"rendered":"<p>Comparing and identifying phenotypic differences between genetically close-related populations is interesting but challenging. Here we attempt to understand the difference between Han Chinese and Japanese via the analysis of gene expression data which we assume to be a proxy measure of phenotypic differences. We first identified expression showing significant differences between the two populations (about 4.4% of the transcriptome). Next we established association between variants on DNA level and the differential expression. Our analysis showed that genetic differences can explain 7 &#8211; 43% of the identified expression differences, many of which are associated with hematological and biochemical traits, or possibly height. (By Dr. Shuhua Xu, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2013\/06\/03\/jmedgenet-2012-101501\">http:\/\/jmg.bmj.com\/content\/early\/2013\/06\/03\/jmedgenet-2012-101501<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Comparing and identifying phenotypic differences between genetically close-related populations is interesting but challenging. Here we attempt to understand the difference between Han Chinese and Japanese via the analysis of gene expression data which we assume to be a proxy measure of phenotypic differences. We first identified expression showing significant differences between the two populations (about [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2013\/06\/04\/identification-of-well-differentiated-gene-expressions-between-han-chinese-and-japanese-using-genome-wide-microarray-data-analysis\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-541","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=541"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/541\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}