{"id":529,"date":"2013-05-10T20:46:01","date_gmt":"2013-05-10T20:46:01","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=529"},"modified":"2013-05-10T20:46:01","modified_gmt":"2013-05-10T20:46:01","slug":"an-x-chromosome-wide-association-analysis-identifies-variants-in-gpr174-as-a-risk-factor-to-graves-disease","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2013\/05\/10\/an-x-chromosome-wide-association-analysis-identifies-variants-in-gpr174-as-a-risk-factor-to-graves-disease\/","title":{"rendered":"An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor to Graves\u2019 disease"},"content":{"rendered":"<p>Graves\u2019 disease is an autoimmune illness mostly seen in female. The contribution of the X chromosomes to its risk has long been appreciated. We re-examined the X chromosome data from our recent study using a technology named genome-wide association study (GWAS). A single nucleotide polymorphism (SNP) which changes an amino acid within the G protein-coupled receptor 174 gene (<i>GPR174<\/i>) \u00a0on Xq21.1, namely rs3827440, was associated with susceptibility to Graves\u2019 disease and the odds ratio was next to that of the <i>HLA<\/i> SNPs, the previously established most significant locus related to this disease. Resequencing results revealed other rare variants of <i>GPR174<\/i> also contributed to disease risk. <i>GPR174 <\/i>is widely expressed in immune-related tissues and might serve as a potential drug target in future studies. The finding of an X-linked risk locus for Graves\u2019 disease expands our understanding of the role played by X chromosome in the pathogenesis of autoimmune diseases. (Professor Wei Huang, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2013\/05\/09\/jmedgenet-2013-101595\">http:\/\/jmg.bmj.com\/content\/early\/2013\/05\/09\/jmedgenet-2013-101595<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Graves\u2019 disease is an autoimmune illness mostly seen in female. The contribution of the X chromosomes to its risk has long been appreciated. We re-examined the X chromosome data from our recent study using a technology named genome-wide association study (GWAS). A single nucleotide polymorphism (SNP) which changes an amino acid within the G protein-coupled [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2013\/05\/10\/an-x-chromosome-wide-association-analysis-identifies-variants-in-gpr174-as-a-risk-factor-to-graves-disease\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-529","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/529","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=529"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/529\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=529"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=529"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=529"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}