{"id":506,"date":"2013-03-28T18:41:35","date_gmt":"2013-03-28T18:41:35","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=506"},"modified":"2013-03-28T18:41:35","modified_gmt":"2013-03-28T18:41:35","slug":"ovarian-cancer-among-8005-women-from-a-breast-cancer-family-history-clinic-no-increased-risk-of-invasive-ovarian-cancer-in-families-testing-negative-for-brca1-and-brca2","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2013\/03\/28\/ovarian-cancer-among-8005-women-from-a-breast-cancer-family-history-clinic-no-increased-risk-of-invasive-ovarian-cancer-in-families-testing-negative-for-brca1-and-brca2\/","title":{"rendered":"Ovarian cancer among 8005 women from a breast cancer family history clinic: No increased risk of invasive ovarian cancer in families testing negative for BRCA1 and BRCA2"},"content":{"rendered":"<p>Families with mutations in <i>BRCA1<\/i>\/<i>BRCA2<\/i> genes have a high-risk of both breast and ovarian cancer.\u00a0 We examined whether there was increased ovarian cancer risk in families which were untested or tested negative for <i>BRCA1\/2 <\/i>mutations.\u00a0 By performing person-years at risk analyses on 8005 women from 895 families we found there to be no increased risk of ovarian cancer in families that tested negative for <i>BRCA1 <\/i>\/<i>BRCA2<\/i>, or were untested, compared to the general population.\u00a0 Our findings can help with counselling women from <i>BRCA1\/2 <\/i>negative families with breast cancer that their risk of invasive ovarian cancer is not higher than the general population. (By Dr. Sarah Ingham, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2013\/03\/27\/jmedgenet-2013-101607\">http:\/\/jmg.bmj.com\/content\/early\/2013\/03\/27\/jmedgenet-2013-101607<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Families with mutations in BRCA1\/BRCA2 genes have a high-risk of both breast and ovarian cancer.\u00a0 We examined whether there was increased ovarian cancer risk in families which were untested or tested negative for BRCA1\/2 mutations.\u00a0 By performing person-years at risk analyses on 8005 women from 895 families we found there to be no increased risk [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2013\/03\/28\/ovarian-cancer-among-8005-women-from-a-breast-cancer-family-history-clinic-no-increased-risk-of-invasive-ovarian-cancer-in-families-testing-negative-for-brca1-and-brca2\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-506","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/506","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=506"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/506\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=506"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=506"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}