Sarcoidosis is a systemic granulomatous disorder most commonly affecting the lung. While we do not know its cause\/s, there is compelling evidence that a genetic predisposition to developing the disease exists. However, <\/b>sarcoidosis is not a single-gene disorder; instead, it is likely to result from a complex interplay of multiple genes and environmental factors. The host genetic profile is also likely to account for the wide variety of observed clinical manifestations, outcomes, and response to treatment.<\/p>\n
The aim of this review is to discuss recent advances in genetics of sarcoidosis – with emphasis on recently performed genome-wide association studies – as well as practical issues and implications for both patients and physicians of such progress. (By Dr. Paolo Spagnolo, http:\/\/jmg.bmj.com\/content\/early\/2013\/03\/21\/jmedgenet-2013-101532<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":" Sarcoidosis is a systemic granulomatous disorder most commonly affecting the lung. While we do not know its cause\/s, there is compelling evidence that a genetic predisposition to developing the disease exists. However, sarcoidosis is not a single-gene disorder; instead, it is likely to result from a complex interplay of multiple genes and environmental factors. The […]<\/p>\n