{"id":470,"date":"2013-02-22T19:32:42","date_gmt":"2013-02-22T19:32:42","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=470"},"modified":"2013-02-27T13:48:32","modified_gmt":"2013-02-27T13:48:32","slug":"arhgdia-a-novel-gene-implicated-in-nephrotic-syndrome","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2013\/02\/22\/arhgdia-a-novel-gene-implicated-in-nephrotic-syndrome\/","title":{"rendered":"ARHGDIA: a novel gene implicated in nephrotic syndrome"},"content":{"rendered":"<p>Congenital nephrotic syndrome is a rare kidney disease in which affected infants lose protein in the urine and eventually develop kidney failure.\u00a0 Most cases are due to mutations in one of five genes.\u00a0 We have identified a mutation in a new gene, <i>ARHGDIA,<\/i> encoding Rho GDP dissociation inhibitor alpha (RhoGDIa) that is responsible for this disorder in two sisters. RhoGDIa interacts with a family of proteins called the Rho-family of small GTPases that regulate the structure and motility of cells.\u00a0 Our data demonstrates that the mutation in <i>ARHGDIA<\/i> disrupts the function of cells within the kidney that normally prevent the loss of protein.\u00a0 (By Dr. Indra Gupta, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2013\/02\/21\/jmedgenet-2012-101442\">http:\/\/jmg.bmj.com\/content\/early\/2013\/02\/21\/jmedgenet-2012-101442<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Congenital nephrotic syndrome is a rare kidney disease in which affected infants lose protein in the urine and eventually develop kidney failure.\u00a0 Most cases are due to mutations in one of five genes.\u00a0 We have identified a mutation in a new gene, ARHGDIA, encoding Rho GDP dissociation inhibitor alpha (RhoGDIa) that is responsible for this [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2013\/02\/22\/arhgdia-a-novel-gene-implicated-in-nephrotic-syndrome\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-470","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/470","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=470"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/470\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=470"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=470"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}