{"id":440,"date":"2013-01-13T02:08:04","date_gmt":"2013-01-13T02:08:04","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=440"},"modified":"2013-02-27T13:48:33","modified_gmt":"2013-02-27T13:48:33","slug":"mutations-of-nanos1-a-human-homologue-of-the-drosophila-morphogen-are-associated-with-a-lack-of-germ-cells-in-testes-or-severe-oligo-astheno-teratozoospermia","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2013\/01\/13\/mutations-of-nanos1-a-human-homologue-of-the-drosophila-morphogen-are-associated-with-a-lack-of-germ-cells-in-testes-or-severe-oligo-astheno-teratozoospermia\/","title":{"rendered":"Mutations of NANOS1, a human homologue of the Drosophila morphogen, are associated with a lack of germ cells in testes or severe oligo-astheno-teratozoospermia"},"content":{"rendered":"<p>The genetic causes of infertility are not well understood, while they seem quite frequent. We found that mutations of a gene, <i>NANOS1<\/i>, are possibly among the causes of human male reproduction failure, as they are in the fruit fly. Depending on location within the gene, these mutations can cause a complete lack of germ cells in testes or abnormal spermatozoa. This is the first report describing an association of <i>NANOS1<\/i> gene mutations with a human disease. More studies are needed however, to uncover whether testing of <i>NANOS1<\/i> gene mutations could be relevant for diagnosis of infertile couples. (By Dr. Jadwiga Jaruzelska, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2013\/01\/11\/jmedgenet-2012-101230\">http:\/\/jmg.bmj.com\/content\/early\/2013\/01\/11\/jmedgenet-2012-101230<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The genetic causes of infertility are not well understood, while they seem quite frequent. We found that mutations of a gene, NANOS1, are possibly among the causes of human male reproduction failure, as they are in the fruit fly. Depending on location within the gene, these mutations can cause a complete lack of germ cells [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2013\/01\/13\/mutations-of-nanos1-a-human-homologue-of-the-drosophila-morphogen-are-associated-with-a-lack-of-germ-cells-in-testes-or-severe-oligo-astheno-teratozoospermia\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-440","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/440","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=440"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/440\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=440"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=440"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=440"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}