{"id":419,"date":"2012-12-15T05:36:28","date_gmt":"2012-12-15T05:36:28","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=419"},"modified":"2013-02-27T13:48:33","modified_gmt":"2013-02-27T13:48:33","slug":"il12b-snps-and-copy-number-variation-in-il23r-gene-associate-with-susceptibility-to-leprosy","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2012\/12\/15\/il12b-snps-and-copy-number-variation-in-il23r-gene-associate-with-susceptibility-to-leprosy\/","title":{"rendered":"IL12B SNPs and Copy number variation in IL23R gene associate with susceptibility to leprosy"},"content":{"rendered":"<p>Leprosy,a chronic infectious disease, continues to remain an important health problem in developing countries including India. The susceptibility to leprosy involves strong host genetic components inherited at birth. In a replicative case-control study from India, we identified the genetic variant in a pro-inflammatory IL12B cytokine gene subunit with a strong association with leprosy susceptibility, probably by affecting the binding of splicing factor(s). Gene-gene interaction analysis at multiple risk loci highlighted the importance of specific genetic backgrounds of immune response related genes in the outcome of <i>M. leprae<\/i> infection. Further a preliminary study, using a subset of samples, showed the increase in copy number of IL23R gene associated with pauci-bacillary form of leprosy which correlated with a trend towards enhanced expression in memory T cells. (By Prof. R.N.K.Bamezai, <a href=\"http:\/\/jmg.bmj.com\/content\/50\/1\/34\">http:\/\/jmg.bmj.com\/content\/50\/1\/34<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Leprosy,a chronic infectious disease, continues to remain an important health problem in developing countries including India. The susceptibility to leprosy involves strong host genetic components inherited at birth. In a replicative case-control study from India, we identified the genetic variant in a pro-inflammatory IL12B cytokine gene subunit with a strong association with leprosy susceptibility, probably [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2012\/12\/15\/il12b-snps-and-copy-number-variation-in-il23r-gene-associate-with-susceptibility-to-leprosy\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-419","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/419","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=419"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/419\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=419"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=419"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}