{"id":214,"date":"2011-11-03T18:54:53","date_gmt":"2011-11-03T18:54:53","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=214"},"modified":"2011-11-03T18:54:53","modified_gmt":"2011-11-03T18:54:53","slug":"sex-differences-in-reproductive-fitness-contribute-to-preferential-maternal-transmission-of-22q11-2-deletions","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2011\/11\/03\/sex-differences-in-reproductive-fitness-contribute-to-preferential-maternal-transmission-of-22q11-2-deletions\/","title":{"rendered":"Sex differences in reproductive fitness contribute to preferential maternal transmission of 22q11.2 deletions"},"content":{"rendered":"<p>22q11.2 deletion syndrome (22q11.2DS) is one of the most common\u00a0 genetic syndromes in humans. For the first time in history, most with\u00a0 22q11.2DS are living to adulthood, and there is a 1 in 2 chance of\u00a0 passing on the condition to a child. We compared the number of\u00a0children born to adults with 22q11.2DS with the number born to their\u00a0brothers and sisters without 22q11.2DS. Few with 22q11.2DS have\u00a0children, apparently not related to heart defects but possibly because\u00a0they find it hard to meet a partner. Those who do are more often\u00a0women.\u00a0There is a subgroup of women with 22q11.2DS who have about as\u00a0many children as their sisters. This may be why more inherited cases\u00a0are from a mother than a father. We also observed that men with\u00a022q11.2DS are more likely to pass on the condition to their sons than\u00a0daughters. (By Dr Anne S Bassett, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2011\/11\/02\/jmedgenet-2011-100440.abstract?papetoc\">http:\/\/jmg.bmj.com\/content\/early\/2011\/11\/02\/jmedgenet-2011-100440.abstract?papetoc<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>22q11.2 deletion syndrome (22q11.2DS) is one of the most common\u00a0 genetic syndromes in humans. For the first time in history, most with\u00a0 22q11.2DS are living to adulthood, and there is a 1 in 2 chance of\u00a0 passing on the condition to a child. We compared the number of\u00a0children born to adults with 22q11.2DS with the [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2011\/11\/03\/sex-differences-in-reproductive-fitness-contribute-to-preferential-maternal-transmission-of-22q11-2-deletions\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-214","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/214","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=214"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/214\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=214"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=214"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=214"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}