{"id":125,"date":"2011-03-18T17:08:35","date_gmt":"2011-03-18T17:08:35","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=125"},"modified":"2011-03-18T17:08:35","modified_gmt":"2011-03-18T17:08:35","slug":"germline-palb2-mutation-analysis-in-breast%e2%80%93pancreas-cancer-families","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2011\/03\/18\/germline-palb2-mutation-analysis-in-breast%e2%80%93pancreas-cancer-families\/","title":{"rendered":"Germline PALB2 mutation analysis in breast\u2013pancreas cancer families"},"content":{"rendered":"<p>Genetic mutations in the <em>PALB2<\/em> gene have been implicated in predisposition to pancreatic cancer as well as breast cancer. The goal of this study was to evaluate whether<em> PALB2<\/em> mutations are also found in families that have a history of both breast and pancreatic cancers. In 77 breast-pancreas cancer families, including 22 patients with a personal history of both breast cancer and pancreatic cancer, we did not find any mutations in the <em>PALB2<\/em> gene. As such, routine genetic screening of breast-pancreas cancer families for the <em>PALB2<\/em> genetic mutation is likely to be low yield. (By Zsofia K. Stadler, MD, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2011\/03\/16\/jmg.2010.087379.abstract?papetoc\">http:\/\/jmg.bmj.com\/content\/early\/2011\/03\/16\/jmg.2010.087379.abstract?papetoc<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Genetic mutations in the PALB2 gene have been implicated in predisposition to pancreatic cancer as well as breast cancer. The goal of this study was to evaluate whether PALB2 mutations are also found in families that have a history of both breast and pancreatic cancers. In 77 breast-pancreas cancer families, including 22 patients with a [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2011\/03\/18\/germline-palb2-mutation-analysis-in-breast%e2%80%93pancreas-cancer-families\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-125","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/125","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=125"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/125\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=125"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=125"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}