{"id":1076,"date":"2018-01-12T19:30:50","date_gmt":"2018-01-12T19:30:50","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=1076"},"modified":"2018-01-12T19:30:50","modified_gmt":"2018-01-12T19:30:50","slug":"role-of-germline-aberrations-affecting-ctnna1-map3k6-and-myd88-in-gastric-cancer-susceptibility","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2018\/01\/12\/role-of-germline-aberrations-affecting-ctnna1-map3k6-and-myd88-in-gastric-cancer-susceptibility\/","title":{"rendered":"Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric cancer susceptibility"},"content":{"rendered":"<p>In Northern Europe familial clustering is seen in 10-20% of gastric cancer patients. In fewer than 3% a pathogenic variant in CDH1, the most important gene involved in hereditary gastric cancer, is detected. The majority of gastric cancer families remain genetically unexplained. We have sequenced a large cohort of unexplained familial gastric cancer patients for mutations in three recently described possible predisposition genes: CTNNA1, MAP3K6 and MYD88. Our data support that mutations in CTNNA1, but not MAP3K6, are a rare cause of gastric cancer susceptibility. No additional MYD88 mutations were detected suggesting that these are at most very rarely involved. (By Chella van der Post and Dr. Marjolijn Ligtenberg, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2018\/01\/12\/jmedgenet-2017-104962\">http:\/\/jmg.bmj.com\/content\/early\/2018\/01\/12\/jmedgenet-2017-104962<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In Northern Europe familial clustering is seen in 10-20% of gastric cancer patients. In fewer than 3% a pathogenic variant in CDH1, the most important gene involved in hereditary gastric cancer, is detected. The majority of gastric cancer families remain genetically unexplained. We have sequenced a large cohort of unexplained familial gastric cancer patients for [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2018\/01\/12\/role-of-germline-aberrations-affecting-ctnna1-map3k6-and-myd88-in-gastric-cancer-susceptibility\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1076","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1076","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=1076"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1076\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=1076"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=1076"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=1076"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}