{"id":1051,"date":"2017-10-27T18:37:39","date_gmt":"2017-10-27T18:37:39","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=1051"},"modified":"2017-10-27T18:37:39","modified_gmt":"2017-10-27T18:37:39","slug":"genome-wide-association-study-identified-copy-number-variants-associated-with-sporadic-colorectal-cancer-risk","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2017\/10\/27\/genome-wide-association-study-identified-copy-number-variants-associated-with-sporadic-colorectal-cancer-risk\/","title":{"rendered":"Genome-wide association study identified copy number variants associated with sporadic colorectal cancer risk"},"content":{"rendered":"<p>Colorectal Cancer (CRC) is the third most frequent cancer worldwide and associated with high mortality. We identified a rare structural or copy number variant region (CNVR) encompassing a chromatin remodeler (<em>CHD8<\/em>) and two common CNVRs encompassing an anti-phagocytic molecule (<em>CD47<\/em>) and two members of the RAS superfamily of GTPases (<em>RERG<\/em>\/<em>ARHGDIB<\/em>) respectively in the human genome associated with sporadic CRC risk. Notably, majority of autistic patients with <em>CHD8 <\/em>loss had gastrointestinal defect including CRC, thus supporting <em>CHD8<\/em> role as an important regulator of tumorigenesis. <em>\u00a0<\/em>Understanding the role of CNVs provides insights into CRC biology and potential biomarkers for future risk assessment. (By Dr. Peh Yean CHEAH, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2017\/10\/27\/jmedgenet-2017-104913\">http:\/\/jmg.bmj.com\/content\/early\/2017\/10\/27\/jmedgenet-2017-104913<\/a> )<\/p>\n<p><a href=\"https:\/\/stg-blogs.bmj.com\/jmg\/files\/2017\/10\/1-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1052\" src=\"https:\/\/stg-blogs.bmj.com\/jmg\/files\/2017\/10\/1-1-300x249.jpg\" alt=\"\" width=\"300\" height=\"249\" srcset=\"https:\/\/stg-blogs.bmj.com\/jmg\/files\/2017\/10\/1-1-300x249.jpg 300w, https:\/\/stg-blogs.bmj.com\/jmg\/files\/2017\/10\/1-1-768x637.jpg 768w, https:\/\/stg-blogs.bmj.com\/jmg\/files\/2017\/10\/1-1.jpg 851w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Colorectal Cancer (CRC) is the third most frequent cancer worldwide and associated with high mortality. We identified a rare structural or copy number variant region (CNVR) encompassing a chromatin remodeler (CHD8) and two common CNVRs encompassing an anti-phagocytic molecule (CD47) and two members of the RAS superfamily of GTPases (RERG\/ARHGDIB) respectively in the human genome [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2017\/10\/27\/genome-wide-association-study-identified-copy-number-variants-associated-with-sporadic-colorectal-cancer-risk\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1051","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1051","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=1051"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1051\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=1051"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=1051"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=1051"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}