{"id":1016,"date":"2017-08-16T18:19:25","date_gmt":"2017-08-16T18:19:25","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=1016"},"modified":"2017-08-16T18:19:25","modified_gmt":"2017-08-16T18:19:25","slug":"their-loss-is-our-gain-regressive-evolution-in-vertebrates-provides-genomic-models-for-uncovering-human-disease-loci","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/jmg\/2017\/08\/16\/their-loss-is-our-gain-regressive-evolution-in-vertebrates-provides-genomic-models-for-uncovering-human-disease-loci\/","title":{"rendered":"Their loss is our gain: regressive evolution in vertebrates provides genomic models for uncovering human disease loci"},"content":{"rendered":"<p>What can an armadillo tell us about blindness and an anteater about dental disorders? Many animals have evolved traits that are similar to human genetic diseases, although for these animals the traits are adaptive, not disease-causing. Intriguingly, when animals possess these disease-mimicking traits, they frequently have disabling mutations in the same genes underlying the human genetic disorders. Here we show how medical geneticists can leverage the genomes of these disease-mimicking animals, which range from blue whales to sloths and pangolins to naked mole-rats, to corroborate and discover novel gene-disease associations for diseases related to vision, teeth and other organs. (By Dr. Christopher A Emerling, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2017\/08\/16\/jmedgenet-2017-104837\">http:\/\/jmg.bmj.com\/content\/early\/2017\/08\/16\/jmedgenet-2017-104837<\/a> )<\/p>\n<p><a href=\"https:\/\/stg-blogs.bmj.com\/jmg\/files\/2017\/08\/Darwin.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1017\" src=\"https:\/\/stg-blogs.bmj.com\/jmg\/files\/2017\/08\/Darwin-260x300.jpg\" alt=\"\" width=\"260\" height=\"300\" srcset=\"https:\/\/stg-blogs.bmj.com\/jmg\/files\/2017\/08\/Darwin-260x300.jpg 260w, https:\/\/stg-blogs.bmj.com\/jmg\/files\/2017\/08\/Darwin-768x887.jpg 768w, https:\/\/stg-blogs.bmj.com\/jmg\/files\/2017\/08\/Darwin-887x1024.jpg 887w, https:\/\/stg-blogs.bmj.com\/jmg\/files\/2017\/08\/Darwin-300x346.jpg 300w\" sizes=\"auto, (max-width: 260px) 100vw, 260px\" \/><\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>What can an armadillo tell us about blindness and an anteater about dental disorders? Many animals have evolved traits that are similar to human genetic diseases, although for these animals the traits are adaptive, not disease-causing. Intriguingly, when animals possess these disease-mimicking traits, they frequently have disabling mutations in the same genes underlying the human [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/jmg\/2017\/08\/16\/their-loss-is-our-gain-regressive-evolution-in-vertebrates-provides-genomic-models-for-uncovering-human-disease-loci\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1016","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1016","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=1016"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1016\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=1016"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=1016"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=1016"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}