{"id":638,"date":"2015-03-18T18:00:18","date_gmt":"2015-03-18T18:00:18","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/?p=638"},"modified":"2017-08-21T11:55:46","modified_gmt":"2017-08-21T11:55:46","slug":"primary-care-corner-with-geoffrey-modest-md-zoster-vaccine-waning-protection-after-8-10-years","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/2015\/03\/18\/primary-care-corner-with-geoffrey-modest-md-zoster-vaccine-waning-protection-after-8-10-years\/","title":{"rendered":"Primary Care Corner with Geoffrey Modest MD: Zoster vaccine &#8211; waning protection after 8-10 years"},"content":{"rendered":"<p><strong>By: Dr. Geoffrey Modest<\/strong><\/p>\n<p>The Shingles Prevention Study (SPS) initially demonstrated efficacy of the zoster vaccine for 4 years. The Long-Term Persistance Substudy (LTPS), however, has shown marked decrease efficacy after about 8 years (see<strong>\u00a0doi:\u00a010.1093\/cid\/ciu918<\/strong>\u200b).<\/p>\n<p>Details:<\/p>\n<p>&#8211;6867 SPS vaccine recipients were enrolled in LTPS: 97.8% white, 56.3% men, median age 74.5 with 20.8% older than 80<\/p>\n<p>&#8211;estimated vaccine efficacy decreased in LTPS over the initial SPS values (4 year data)\u00a0from 61.1% to 37.3% for the burden of illness (BOI,\u00a0a measure of the severity-by-duration of zoster pain and discomfort),\u00a0from 66.5% to 35.4% for the incidence of postherpetic neuralgia and from 51.3% to 21.1% for the incidence of clinical zoster itself.<\/p>\n<p>&#8211;statistically, vaccine efficacy for BOI was still significant after 10 years post-vaccination, but for clinical zoster it was only significant for 8 years<\/p>\n<p>&#8211;no additional vaccine-related adverse events in the LTPS over what was reported in\u00a0SPS<\/p>\n<p>&#8211;of note, there was no control population for\u00a0the LTPS study, just historical controls, based on the placebo groups in SPS<\/p>\n<p>So, I&#8217;m really not sure where we are going with some of these vaccines. I\u00a0have posted previous blogs about the apparently quite short (3-4 year) efficacy of the pertussis component of Tdap in adults, given the high frequency of reported pertussis\u00a0outbreaks even in those recently immunized\u00a0(though it is recommended only once in adulthood specifically for the pertussis component). And now the pretty limited efficacy of the zoster vaccine. We will see what the CDC is going to recommend&#8230;..<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zoster vaccine &#8211; waning protection after 8-10 years [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/2015\/03\/18\/primary-care-corner-with-geoffrey-modest-md-zoster-vaccine-waning-protection-after-8-10-years\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":148,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[14283],"tags":[],"class_list":["post-638","post","type-post","status-publish","format-standard","hentry","category-archive"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/posts\/638","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/users\/148"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/comments?post=638"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/posts\/638\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/media?parent=638"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/categories?post=638"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/tags?post=638"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}