{"id":1178,"date":"2016-11-15T14:52:15","date_gmt":"2016-11-15T14:52:15","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/?p=1178"},"modified":"2017-08-21T10:43:28","modified_gmt":"2017-08-21T10:43:28","slug":"primary-care-corner-with-geoffrey-modest-md-meningococcal-vaccine-in-hiv-positive-patients","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/2016\/11\/15\/primary-care-corner-with-geoffrey-modest-md-meningococcal-vaccine-in-hiv-positive-patients\/","title":{"rendered":"Primary Care Corner with Geoffrey Modest MD: Meningococcal vaccine in HIV-positive patients"},"content":{"rendered":"<p><strong>By Dr. Geoffrey Modest<\/strong><\/p>\n<p>There are 2 potentially very serious bacterial\u00a0infections, both with\u00a0functional vaccines available but not previously recommended,\u00a0that seem to be more common in HIV infected patients: HIB (haemophilus influenzae type B) and meningococcus. The Advisory Committee on Immunization Practices, ACIP,\u00a0 just came out with recommendations to immunize HIV-positive patients\u00a0against meningococcus.<\/p>\n<p>Details:<\/p>\n<ol>\n<li>For the HIB infection: I had been immunizing all HIV patients with HIB vaccine until a few years ago, based on a case-control study about 20 years ago showing a higher\u00a0prevalence of invasive\u00a0HIB\u00a0infections in HIV positive patients. Though the data on efficacy were lacking, it seemed to me that the potential benefit far outweighed the very low risk of this tried-and-true vaccine. The current feeling, from my reading, is that while HIV may be a risk factor for invasive\u00a0HIB infections, the incidence of HIB infections overall has plummeted due to the aggressive HIB immunizations of children, dramatically decreasing the HIB reservoir and shifting the serotype of prevalent H flu infections dramatically away from typable\u00a0to nontypables. So, it does\u00a0seems unnecessary to immunize. But, it still may still\u00a0be reasonable to vaccinate\u00a0those patients who come from and return to countries without\u00a0universal pediatric HIB immunization.<\/li>\n<\/ol>\n<ol start=\"2\">\n<li>Meningococcal vaccine: I also began immunizing my HIV patients with meningococcal conjugate vaccine several years ago, after the outbreak of meningococcal disease in HIV-positive people in\u00a0New York, though I stopped a couple\u00a0years ago because of strong and persistent statements by the CDC not to do so. The new\u00a0recommendations, however,\u00a0are\u00a0that\u00a0all HIV-infected persons be immunized pretty aggressively\u00a0(see\u00a0<a href=\"https:\/\/www.cdc.gov\/mmwr\/volumes\/65\/wr\/mm6543a3.htm?s_cid=mm6543a3_x\">https:\/\/www.cdc.gov\/mmwr\/volumes\/65\/wr\/mm6543a3.htm?s_cid=mm6543a3_x<\/a> ).<\/li>\n<\/ol>\n<ul>\n<li>Those\u00a0&lt; 2 years old should get\u00a0MenACWY-CRM (Menveo) at\u00a02, 4, 6, and 12-15 months, or\u00a0get MenACWY-D\u00a0(Menactra)\u00a0at\u00a0ages 9-23 months and then 12 weeks later (with the caveats that this last one be given: only if &gt;4 weeks after finishing the pneumococcal conjugate vaccine and either before or concomitantly\u00a0with\u00a0DTaP &#8212;\u00a0see below)<\/li>\n<li>Those &gt; 2 years old and not previously vaccinated\u00a0should get a 2-dose primary series of the conjugate vaccine (either of the above), 8-12 weeks apart<\/li>\n<li>Those\u00a0who had most recent vaccine dose\u00a0&lt; age\u00a07 years\u00a0should get a booster 3 years later, then <strong>every 5 years thereafter<\/strong><\/li>\n<li>Those\u00a0who had most recent vaccine dose &gt;\u00a0age\u00a07\u00a0years\u00a0should get a\u00a0booster 5 years later, <strong>and every 5 years throughout life<\/strong>.<\/li>\n<li>The immunogenicity study (comparing a single vs a series of 2 vaccines in patients with\u00a0CD4 percent&gt;15%) noted serious adverse events in 2.2-6.5% six\u00a0weeks post-vaccination, the number of adverse events being inversely related to CD4 percent, and only one of the serious adverse events (ocular pain)\u00a0felt to be related to MenACWY-D. A study in kids aged 2-10 found 5% had a serious adverse event, but none felt to be attributable to the vaccine<\/li>\n<li>Overall, from a lifetime perspective, vaccination was calculated to lead to the prevention of\u00a0approx 122 cases of meningococcal disease and 23 deaths, and 385 quality-adjusted life years (QALY)\u00a0could be saved, with mean cost of $732,000 per QALY if the primary series of vaccines and lifelong boosters every 5 years were given.<\/li>\n<\/ul>\n<p>Commentary:<\/p>\n<ul>\n<li>The risk of meningococcal infection in HIV patients, from data from the US, UK, and South Africa, is 5-13x that of non-HIV infected, with prevalence of 3.6-6.6 per 100,000, and with a case-fatality rate that\u00a0is a bit mixed: those with HIV in South Africa had about twice the meningococcal case fatality rate (20% vs 11%), though this was not found in New York or the UK.<\/li>\n<li>The risk of meningococcal disease is higher in those with high viral loads or low CD4 counts, though the immunogenicity of the vaccine is about 50% lower in those with lower CD4 counts (i.e., better to wait until the CD4 increases in those with uncontrolled infections,\u00a0though unclear exactly what the cut-point here is from the studies. The one study the MMWR quoted used the CD4\u00a0cutpoint of 200 from a New York study, finding a 5.3-fold increased risk with CD4&lt;200). Similar risk in men and women.<\/li>\n<li>The majority of meningococcal infections in HIV-infected people are of serogroups A,C,W, and Y. One issue is that the largest database, the passive National Notifiable Diseases Surveillance System, does not include HIV status. The Active Bacterial Core surveillance (ABCs), a smaller database from 10 sites and representing 14% of the US population, does include HIV status. Based on these somewhat limited data, there were 62 cases of meningococcal disease in HIV-infected patients from 1995-2015, 13% were serogroup B and 10% were of unknown serotypes; 92% of cases were in people aged 20-59 years old<\/li>\n<li>They do note that the only licensed vaccine for those &gt;55 years old is the meningococcal polysaccharide vaccine;\u00a0they still recommend the MenACWY conjugate vaccine,\u00a0based on limited data.<\/li>\n<li>The recommendations\u00a0for infants 2-23 months are complex:\u00a0they recommend the MenACWY-CRM and not the MenACWY-D because of potential immune interference with the PCV conjugate vaccine with the latter,\u00a0as well as potential interference of\u00a0DTaP with\u00a0MenACWY-D if the\u00a0MenACWY-D\u00a0was\u00a0given 30 days after the DTaP, but not if the 2 are given simultaneously or if the MenACWY-D\u00a0is given first<\/li>\n<li>Ndata on efficacy or adverse events if meningococcal vaccine given during pregnancy or lactation<\/li>\n<li>So, the bottom line for me: I\u00a0do plan to restart giving HIB vaccine to HIV-infected patients who are going back and forth to countries without routine HIB vaccination for kids (not CDC recommended, but makes sense to me). in addition, i will adopt the meningococcal conjugate vaccine according to the ACIP\u00a0schedule above, including the booster immunization every 5 years, though i will wait until the CD4 increases to a level of &gt;15% or until it plateaus at its highest CD4 percent (using the CD4 percent, as in the studies they quoted:\u00a0there was\u00a0no mention of the absolute CD4 count). I will also wait until the viral load is suppressed, since the limited data found a better response if the viral load was lower, in one of the studies if\u00a0&lt;400. The CDC does not mention anything about meningococcal serogroup B vaccination,\u00a0but i would consider using the meningococcal B vaccine if there were a local outbreak of serogroup B infections (though my literature search revealed nothing on the immunogenicity or efficacy of that vaccine in HIV-positive patients).<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Primary Care Corner with Geoffrey Modest MD: Meningococcal vaccine in HIV-positive patients [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/2016\/11\/15\/primary-care-corner-with-geoffrey-modest-md-meningococcal-vaccine-in-hiv-positive-patients\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":148,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[14283],"tags":[],"class_list":["post-1178","post","type-post","status-publish","format-standard","hentry","category-archive"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/posts\/1178","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/users\/148"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/comments?post=1178"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/posts\/1178\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/media?parent=1178"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/categories?post=1178"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmjebmspotlight\/wp-json\/wp\/v2\/tags?post=1178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}