{"id":49,"date":"2006-11-27T15:32:17","date_gmt":"2006-11-27T14:32:17","guid":{"rendered":"http:\/\/resource.bmj.com\/bmj\/2006\/11\/27\/ann-intern-med-21-nov-2006\/"},"modified":"2006-11-27T15:32:17","modified_gmt":"2006-11-27T14:32:17","slug":"ann-intern-med-21-nov-2006","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/bmj\/2006\/11\/27\/ann-intern-med-21-nov-2006\/","title":{"rendered":"Ann Intern Med 21 Nov 2006"},"content":{"rendered":"<p>I\u2019m sure that <a href=\"http:\/\/www.annals.org\/cgi\/content\/full\/145\/10\/749\">individual susceptibility to the effect of drugs<\/a> has been known from before the dawn of civilisation: in oral epics, most chieftains hold their drink better than underlings. As soon as there was Mendelian genetics, there was <a href=\"http:\/\/www.annals.org\/cgi\/content\/full\/145\/10\/749\">phamacogenetics <\/a>\u2013 the linking of particular genes to particular drug responses. Now we have <a href=\"http:\/\/www.annals.org\/cgi\/content\/full\/145\/10\/749\">pharmacogenomics <\/a><!--more-->\u2013 the linkage of drug responses to actual, measurable genomic variation. So, hey, we\u2019ll soon be able to feed our DNA profile into a computer and it\u2019ll tell us exactly which drugs we\u2019ll respond to. Not simply, and certainly not soon, as this measured and learned <a href=\"http:\/\/www.annals.org\/cgi\/content\/full\/145\/10\/749\">review <\/a>indicates. And, by the way, it includes a glossary which is a useful place to look up your basic pharmacological terminology.<\/p>\n<p>I tend to be imperturbable in the face of killer bug threats, but <em>c\u2019est difficile <\/em>in the face of the <a href=\"http:\/\/www.annals.org\/cgi\/content\/full\/145\/10\/758\">latest strain of <em>C difficile<\/em><\/a>. Also let it be known that boring old relics like me with a northern grammar school education will insist that the adjective which agrees with <em>Clostidium <\/em>is the neuter form of Latin <em>difficilis <\/em>and cannot be pronounced like the French word, but the media decrees (<em>o tempora!<\/em><em>difficile <\/em>to diagnose as there is no standard test. The more cephalosporins and quinolones you use, the more you encourage it. sic false agreements! sic mispronunciations!) otherwise. There, I had to get that off my chest. All this is bad news. The blasted new diffikillay resists all known treatments and kills a lot of patients who get it, as it produces much more toxin. It is <em>difficile <\/em>to diagnose as there is no standard test. The more cephalosporins and quinolones you use, the more you encourage it.<\/p>\n<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>I\u2019m sure that individual susceptibility to the effect of drugs has been known from before the dawn of civilisation: in oral epics, most chieftains hold their drink better than underlings. As soon as there was Mendelian genetics, there was phamacogenetics \u2013 the linking of particular genes to particular drug responses. Now we have pharmacogenomics [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/bmj\/2006\/11\/27\/ann-intern-med-21-nov-2006\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":38363,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[111],"tags":[],"class_list":["post-49","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-richard-lehmans-weekly-review-of-medical-journals"],"jetpack_featured_media_url":"https:\/\/stg-blogs.bmj.com\/bmj\/files\/2017\/02\/richard-lehman.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/posts\/49","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/comments?post=49"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/posts\/49\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/media\/38363"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/media?parent=49"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/categories?post=49"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/tags?post=49"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}