{"id":163,"date":"2007-03-26T10:48:47","date_gmt":"2007-03-26T09:48:47","guid":{"rendered":"http:\/\/resource.bmj.com\/bmj\/2007\/03\/26\/lancet-24-mar-2007-vol-369\/"},"modified":"2007-03-26T10:48:47","modified_gmt":"2007-03-26T09:48:47","slug":"lancet-24-mar-2007-vol-369","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/bmj\/2007\/03\/26\/lancet-24-mar-2007-vol-369\/","title":{"rendered":"Lancet  24 Mar 2007"},"content":{"rendered":"<p>In <a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140673607604966\/abstract\">this proof-of-concept study<\/a>, cervical vertebral discs were removed from cadavers and transplanted into matched patients with degenerative disease of the cervical spine.<!--more--> I put it this way round because for every suitable cadaver, there will always be lots of suitable patients: after all, a degenerating cervical spine is part of the human condition. The grafts took within three months and we haven\u2019t a clue what happens after that.<\/p>\n<p>The <a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140673607604607\/abstract\">SANAD trial<\/a> is a large British unblinded trial aimed at discovering which anticonvulsant is the best choice for first-line treatment of partial epilepsy. Current guidelines suggest carbamazepine but lamotrigine was superior in time to treatment failure in this comparison which also included gabapentin, oxcarbazine and topiramate.<br \/>\n<a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140673607604619\/abstract\"><br \/>\nThe other arm of the SANAD study<\/a> looked at generalised or unclassified epilepsy, for which sodium valproate is currently the recommended first-line drug. This trial confirms that: valproate is better tolerated than topiramate and more effective than lamotrigine, which were the other drugs randomly allocated in this part of the study. It is called a \u201ccontrolled trial<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In this proof-of-concept study, cervical vertebral discs were removed from cadavers and transplanted into matched patients with degenerative disease of the cervical spine. [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/bmj\/2007\/03\/26\/lancet-24-mar-2007-vol-369\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":38363,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[111],"tags":[],"class_list":["post-163","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-richard-lehmans-weekly-review-of-medical-journals"],"jetpack_featured_media_url":"https:\/\/stg-blogs.bmj.com\/bmj\/files\/2017\/02\/richard-lehman.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/posts\/163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/comments?post=163"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/posts\/163\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/media\/38363"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/media?parent=163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/categories?post=163"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/tags?post=163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}