{"id":141,"date":"2007-03-12T10:19:01","date_gmt":"2007-03-12T09:19:01","guid":{"rendered":"http:\/\/resource.bmj.com\/bmj\/2007\/03\/12\/nejm-8-mar-2007-vol-356\/"},"modified":"2007-03-12T10:19:01","modified_gmt":"2007-03-12T09:19:01","slug":"nejm-8-mar-2007-vol-356","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/bmj\/2007\/03\/12\/nejm-8-mar-2007-vol-356\/","title":{"rendered":"NEJM  8 Mar 2007  Vol 356"},"content":{"rendered":"<p>It all began more than a hundred years ago, when a London dentist, Charles Stent, devised a little metal structure to hold in place gingival grafts. His name bears a fortuitous resemblance to the Indo-European root for stand and stay (etc) so it does nicely for the purpose.<!--more--><\/p>\n<p>Tubular stents have been tried in all sorts of blocked internal tubes, for the last decade above all in the<a href=\"http:\/\/content.nejm.org\/cgi\/content\/full\/356\/10\/981\"> coronary arteries<\/a>. Bare metal ones are prone to block early, especially in patients who show immune activation against the metal, and to counteract this stents have been armed with different kinds of <a href=\"http:\/\/content.nejm.org\/cgi\/content\/full\/356\/10\/984\">immune suppressant<\/a>, including local radioactivity, which caused coronary artery fibrosis. After a <a href=\"http:\/\/content.nejm.org\/cgi\/content\/full\/356\/10\/989\">profusion of trials<\/a> with exotic acronyms, the Stent Wars narrowed down to single combat between stents coated with two agents, <a href=\"http:\/\/content.nejm.org\/cgi\/content\/full\/356\/10\/998\">sirolimus and paclitaxel<\/a>, which leach out (\u201celute<\/p>\n","protected":false},"excerpt":{"rendered":"<p>It all began more than a hundred years ago, when a London dentist, Charles Stent, devised a little metal structure to hold in place gingival grafts. His name bears a fortuitous resemblance to the Indo-European root for stand and stay (etc) so it does nicely for the purpose. [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/bmj\/2007\/03\/12\/nejm-8-mar-2007-vol-356\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":38363,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[111],"tags":[],"class_list":["post-141","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-richard-lehmans-weekly-review-of-medical-journals"],"jetpack_featured_media_url":"https:\/\/stg-blogs.bmj.com\/bmj\/files\/2017\/02\/richard-lehman.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/posts\/141","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/comments?post=141"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/posts\/141\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/media\/38363"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/media?parent=141"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/categories?post=141"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/tags?post=141"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}