{"id":96,"date":"2010-04-12T21:48:46","date_gmt":"2010-04-12T20:48:46","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/adc-archimedes\/?p=96"},"modified":"2010-04-12T21:48:46","modified_gmt":"2010-04-12T20:48:46","slug":"q-should-you-test-asian-patients-for-hla-b1502-before-presecribing-aeds","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/adc\/2010\/04\/12\/q-should-you-test-asian-patients-for-hla-b1502-before-presecribing-aeds\/","title":{"rendered":"Q: Should you test Asian patients for HLA-B*1502 before presecribing AEDs?"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft\" title=\"HLA-B*1502 of course ...\" src=\"http:\/\/www.iayork.com\/Images\/10-15-07\/HLAB2709.png\" alt=\"\" width=\"72\" height=\"88\" \/>I think this is a fascinating question. In paediatric oncology, we&#8217;re been doing a tiny bit of genetically personalised medicine for a while now, testing the allelic variations of thiopurine metabolisers so we don&#8217;t (over~) poison a small proportion of children with ALL. There are suggestions <!--more-->that similar issues might be around for folk who develop aminoglycoside deafness, or even severe post-chemo vomiting.<\/p>\n<p>But when the question &#8220;Should Phenytoin and Carbamazepine be Avoided in Asian Population with<a title=\"HLA-B*1502 of course...\" href=\"http:\/\/www.iayork.com\/Images\/10-15-07\/HLAB2709.png\"> HLA-B*1502<\/a> Positive Genetic Variant?&#8221; was raised from Leicester, I was delighted to see that non-Oncologists were doing the same sort of questioning.<\/p>\n<p>So do you test, or not?<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>I think this is a fascinating question. In paediatric oncology, we&#8217;re been doing a tiny bit of genetically personalised medicine for a while now, testing the allelic variations of thiopurine metabolisers so we don&#8217;t (over~) poison a small proportion of children with ALL. There are suggestions [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/adc\/2010\/04\/12\/q-should-you-test-asian-patients-for-hla-b1502-before-presecribing-aeds\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[100,82],"tags":[],"class_list":["post-96","post","type-post","status-publish","format-standard","hentry","category-epilepsy","category-therapy"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/posts\/96","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/comments?post=96"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/posts\/96\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/media?parent=96"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/categories?post=96"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/tags?post=96"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}