{"id":1336,"date":"2016-12-18T20:28:06","date_gmt":"2016-12-18T19:28:06","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/adc\/?p=1336"},"modified":"2017-10-30T13:41:06","modified_gmt":"2017-10-30T12:41:06","slug":"cases-and-controls","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/adc\/2016\/12\/18\/cases-and-controls\/","title":{"rendered":"Cases and controls"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-1137\" src=\"https:\/\/stg-blogs.bmj.com\/adc\/files\/2015\/07\/F3.medium-150x150.gif\" alt=\"F3.medium\" width=\"150\" height=\"150\" \/>I&#8217;ve noticed that there are a fair few phrases in the world where there actual meaning can be unclear or uncertain, or possibly interpreted differently by folk. Take &#8220;maybe later&#8221; when used by parent to child &#8211; clearly means &#8220;no&#8221; to the parent and &#8220;yes but not now&#8221; to the child. Or &#8220;brexit&#8221;.<\/p>\n<p>But the world of science can&#8217;t be confused &#8230; \u00a0can it?<\/p>\n<p>Just take a gander through the field of &#8220;case control&#8221; titled studies and you may find yourself upset to discover it can. Now I am fairly clear that what I mean by case\/control is a design where the participants are chosen because they have developed (cases) or haven&#8217;t got (controls) the OUTCOME of interest &#8211; they died, developed neuroblastoma or had exclusion from school. The analysis then is about finding out if these groups had different levels of exposure to a proposed causative factor, such as blood transfusions, bacon, or X-factor viewing.<\/p>\n<p>What is not a case control study is one where the groups are chosen for the exposure to a treatment or not. This is a comparative cohort study.<\/p>\n<p>Now as is so often the case when appraising papers, it doesn&#8217;t sometimes matter what the authors have written. It&#8217;s what they did that counts &#8211; so discount their title if the design doesn&#8217;t fit it.<\/p>\n<p>&nbsp;<\/p>\n<p>&#8211; Archi<\/p>\n<p>&nbsp;<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>I&#8217;ve noticed that there are a fair few phrases in the world where there actual meaning can be unclear or uncertain, or possibly interpreted differently by folk. Take &#8220;maybe later&#8221; when used by parent to child &#8211; clearly means &#8220;no&#8221; to the parent and &#8220;yes but not now&#8221; to the child. Or &#8220;brexit&#8221;. But the [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/adc\/2016\/12\/18\/cases-and-controls\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[79,80],"tags":[],"class_list":["post-1336","post","type-post","status-publish","format-standard","hentry","category-archimedes","category-critical-appraisal-note"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/posts\/1336","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/comments?post=1336"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/posts\/1336\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/media?parent=1336"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/categories?post=1336"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/tags?post=1336"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}