{"id":1254,"date":"2016-02-23T21:00:51","date_gmt":"2016-02-23T20:00:51","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/adc\/?p=1254"},"modified":"2016-02-12T23:07:10","modified_gmt":"2016-02-12T22:07:10","slug":"statsminiblog-trial-sequential-analysis","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/adc\/2016\/02\/23\/statsminiblog-trial-sequential-analysis\/","title":{"rendered":"StatsMiniBlog: Trial Sequential Analysis"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-1164\" src=\"https:\/\/stg-blogs.bmj.com\/adc\/files\/2015\/09\/calculator-97842_640-150x150.png\" alt=\"calculator\" width=\"150\" height=\"150\" \/>You might have seen this &#8220;Trial Sequential Analysis&#8221; in the odd systematic review or meta-analysis, and seen some strange graphs with &#8216;cumulative z-score boundaries&#8217; in them. And then either quickly closed the PDF or flicked away to catch up with an episode of Peppa Pig.<\/p>\n<p>But fear not. TSA is not as strange an idea as it&#8217;s often displayed.<\/p>\n<p>You know that in trials, when they do the interim analysis, they need to account for the fact that many looks at the data might increase the risk of a false positive result?<\/p>\n<p>It&#8217;s just that sort of thing, but applied to meta-analysis.<\/p>\n<p>See &#8211; simple.<\/p>\n<p>But if that was too stressful &#8230;\u00a0<!--more--><\/p>\n<p><a href=\"http:\/\/giphy.com\/gifs\/family-pig-muddy-LPzYvwHkM292M\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1255 size-medium\" src=\"https:\/\/stg-blogs.bmj.com\/adc\/files\/2016\/02\/giphy-300x169.gif\" alt=\"Peppa in Puddles\" width=\"300\" height=\"169\" \/><\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>You might have seen this &#8220;Trial Sequential Analysis&#8221; in the odd systematic review or meta-analysis, and seen some strange graphs with &#8216;cumulative z-score boundaries&#8217; in them. And then either quickly closed the PDF or flicked away to catch up with an episode of Peppa Pig. But fear not. TSA is not as strange an idea [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/adc\/2016\/02\/23\/statsminiblog-trial-sequential-analysis\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[2676],"tags":[],"class_list":["post-1254","post","type-post","status-publish","format-standard","hentry","category-stats"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/posts\/1254","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/comments?post=1254"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/posts\/1254\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/media?parent=1254"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/categories?post=1254"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/tags?post=1254"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}