{"id":101,"date":"2010-05-09T21:15:22","date_gmt":"2010-05-09T20:15:22","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/adc-archimedes\/2010\/05\/09\/do-children-and-adults-really-differ\/"},"modified":"2013-03-15T17:16:29","modified_gmt":"2013-03-15T16:16:29","slug":"do-children-and-adults-really-differ","status":"publish","type":"post","link":"https:\/\/stg-blogs.bmj.com\/adc\/2010\/05\/09\/do-children-and-adults-really-differ\/","title":{"rendered":"Do children and adults really differ?"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft\" title=\"Three UK Party Leaders\" src=\"http:\/\/www.independent.co.uk\/multimedia\/archive\/00250\/brown-cameron-clegg_250220s.jpg\" alt=\"\" width=\"198\" height=\"135\" \/> @giordanopg recently tweeted a link about a <a title=\"Comparative Effectiveness of Medical Interventions in Adults Versus Children\" href=\"http:\/\/bit.ly\/9ik9kP\">paper <\/a>in pre-publication from The Journal Of Pediatrics. It&#8217;s an analysis of a bunch of Cochrane reviews that had both child and adult RCTs included in a meta-analysis and asked the question &#8220;Do children and adults really differ?&#8221;<\/p>\n<p>Their technique was to compare the key outcomes by comparing the odds ratios &#8230; and they found that for the majority of cases THERE WAS NO OBSERVABLE DIFFERENCE (overall relative odds ratio 0.96; 95% confidence intervals, 0.86 to 1.08)<!--more--><br \/>\nThis does hide the fact that in only 1 \/ 127 could it be said there was very unlikely to be a difference (ie no more than 20% better or worse), and that in 4 \/ 127 there was evidence of a real, clinically important difference.<br \/>\nHow we read this, I think, depends on where we sit. Do we want to lump &#8230; and draw down adult evidence &#8230; or do we want to particularise, and require truly direct evidence? (Or do we go for a Balanced Parliament and have a bit of both with electoral reform thrown in?)<\/p>\n<p>Acknowledgement: Picture from the Online Independent<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>@giordanopg recently tweeted a link about a paper in pre-publication from The Journal Of Pediatrics. It&#8217;s an analysis of a bunch of Cochrane reviews that had both child and adult RCTs included in a meta-analysis and asked the question &#8220;Do children and adults really differ?&#8221; Their technique was to compare the key outcomes by comparing [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/stg-blogs.bmj.com\/adc\/2010\/05\/09\/do-children-and-adults-really-differ\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[79,80],"tags":[1639],"class_list":["post-101","post","type-post","status-publish","format-standard","hentry","category-archimedes","category-critical-appraisal-note","tag-archimedes-critical-appriasal-note"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/posts\/101","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/comments?post=101"}],"version-history":[{"count":0,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/posts\/101\/revisions"}],"wp:attachment":[{"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/media?parent=101"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/categories?post=101"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stg-blogs.bmj.com\/adc\/wp-json\/wp\/v2\/tags?post=101"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}