Basics. NNT

The NNT – number needed to treat – is thought by many to be a central core of EBMing. (I’d argue that the numbers in EBM are only a small part of the equation – and that understanding the question and the biases inherent in the study design are greater – but I’d still agree […]

Read More…

Populations matter

So, as I occasionally bang on about, I spend a fair bit of time with children and young people with cancer. We do a lot of transfusions of blood components in this population, frequently because we heartlessly pour toxins into them in order to try to kill of their malignancy. We’ve been debating hard recently […]

Read More…

Basics. Size vs. bias

There’s a beautifully clear explanation behind the BMJ-EBM-journal paywall of a concept I’ve been struggling to express for some time, which is partly there in GRADE and partly grounded in common sense. Take the parachute argument — do you really need an RCT for parachutes (as there are survivors of non-‘chuted  falls) — and reductio ad […]

Read More…

Basics. What is evidence based medicine?

Evidence based medicine – EBM – is a framework for thinking. It’s a process. It’s a method. It’s taking the most unbiased, patient-oriented, clinically relevant research, combining that with the wishes and opinions of the child/young person and family before you and integrating your own skills, expertise and resources to co-produce the most appropriate decision […]

Read More…

#TakeoverDay 2013.

Do you know a young person who would want to blog to a worldwide group of children/young people’s clinicians? Run the twitter account of an international journal for a day? Next Friday, 22 November 2013, is the Children’s Takeover Day 2013 in the UK and we at the Archives of Diseases in Childhood, despite the fusty […]

Read More…

Debating devices

It’s really hard to persuade people that devices need evaluation like drugs do. This might be to do with the physical nature of a device: after all, if you can see the new cannula attachment, or special breathing mask, you know what it’s doing and what it must be making. Or it might be in […]

Read More…