Sensitivity and specificity

Sensitivity and specificity are those sorts of things that can really get knickers twisted up something rotten. They sound like something you should be able to understand, they get used as if you understand them, and then you realise … it’s not quite as you thought …   Really diseased  Really not diseased    Test […]

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Basics: Top 5 tips for evidence based paeds

Hot on the heels of my office next door neighbours SoMe course we’re off with a ‘Top Tips’ post. (Anyone who hates the cheesy format can comment below or tweet us @ADC_BMJ.) Please imagine a racing, 5-years-before-you’re-reading-this-pop-tune as your background music. 1. Know your question Know what you’re asking. And know why you’re asking it. […]

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Diagnostic test accuracy

The main things we look for when examining a new diagnostic test are “Is it as good as, or better than our usual one”, “Is it quicker?”, “Is it cheaper?” and “It is easier for patients/less dangerous?” While the latter three questions can be assessed by asking the folk who do the test, asking the […]

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Differential Diagnosis

The essential elements of a differential diagnosis study are, like most of critical appraisal, really simple and straightforward. You need to start with a bunch of children/young people who turn up with the symptom, or symptom-complex, you’re interested in. Ideally, you need these folk to not already be known to have something, to attend a […]

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Basics. How much is enough?

We’ve approached EBM by thinking about it as a framework for thinking, not a checklist to tick though. It’s the combination of patients views, clinical expertise and relevant research. The process is of asking, acquiring, appraising, applying and assessing. But when it comes to applying evidence to answer a question – how much is enough? […]

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Basics. RR, OR and the like

Just a few posts ago, we introduced the idea of NNT as being an ‘absolute’ measure of how effective a treatment is; that is, the number of folk needed to treat to get one extra good result, compared to something else. This can be used to balance against stuff that might be negative – such […]

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