{"id":903,"date":"2016-06-29T19:09:33","date_gmt":"2016-06-29T19:09:33","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=903"},"modified":"2016-06-29T19:09:33","modified_gmt":"2016-06-29T19:09:33","slug":"specifying-the-ovarian-cancer-risk-threshold-of-premenopausal-risk-reducing-salpingo-oophorectomy-for-ovarian-cancer-prevention-a-cost-effectiveness-analysis","status":"publish","type":"post","link":"http:\/\/stg-blogs.bmj.com\/jmg\/2016\/06\/29\/specifying-the-ovarian-cancer-risk-threshold-of-premenopausal-risk-reducing-salpingo-oophorectomy-for-ovarian-cancer-prevention-a-cost-effectiveness-analysis\/","title":{"rendered":"Specifying the ovarian cancer risk threshold of \u2018premenopausal risk-reducing salpingo-oophorectomy\u2019 for ovarian cancer prevention: a cost-effectiveness analysis"},"content":{"rendered":"<p>Risk-reducing surgery to prevent ovarian cancer involves removal of tubes and ovaries. This has traditionally been performed in women at high risk (&gt;1-in-10 chance) of getting ovarian cancer (e.g. BRCA1\/BRCA2 carriers). However, the ovarian cancer risk level at which surgical prevention should be offered has not been previously defined. We undertook a health economic analysis comparing surgical prevention with no surgery at different ovarian cancer risk levels of 2%, 4%, 5%, 6%, 8% and 10% in pre-menopausal women &gt;40 years. We found that surgical prevention is highly cost-effective in women at the \u22654% lifetime risk of ovarian cancer, leading to increased life-expectancy for an incremental cost-effectiveness ratio =\u00a319536\/QALY. Current surgical prevention guidelines should be re-evaluated to reduce the ovarian cancer risk threshold to benefit a number of at-risk women who presently cannot access risk-reducing surgery. (By Dr Ranjit Manchanda, <a href=\"http:\/\/jmg.bmj.com\/content\/early\/2016\/06\/06\/jmedgenet-2016-103800\">http:\/\/jmg.bmj.com\/content\/early\/2016\/06\/06\/jmedgenet-2016-103800<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Risk-reducing surgery to prevent ovarian cancer involves removal of tubes and ovaries. This has traditionally been performed in women at high risk (&gt;1-in-10 chance) of getting ovarian cancer (e.g. BRCA1\/BRCA2 carriers). However, the ovarian cancer risk level at which surgical prevention should be offered has not been previously defined. We undertook a health economic analysis [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"http:\/\/stg-blogs.bmj.com\/jmg\/2016\/06\/29\/specifying-the-ovarian-cancer-risk-threshold-of-premenopausal-risk-reducing-salpingo-oophorectomy-for-ovarian-cancer-prevention-a-cost-effectiveness-analysis\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-903","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=903"}],"version-history":[{"count":0,"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/903\/revisions"}],"wp:attachment":[{"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=903"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=903"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}