{"id":395,"date":"2012-10-10T16:00:55","date_gmt":"2012-10-10T16:00:55","guid":{"rendered":"http:\/\/stg-blogs.bmj.com\/jmg\/?p=395"},"modified":"2012-10-10T16:00:55","modified_gmt":"2012-10-10T16:00:55","slug":"a-600%e2%80%85kb-deletion-syndrome-at-16p11-2-leads-to-energy-imbalance-and-neuropsychiatric-disorders","status":"publish","type":"post","link":"http:\/\/stg-blogs.bmj.com\/jmg\/2012\/10\/10\/a-600%e2%80%85kb-deletion-syndrome-at-16p11-2-leads-to-energy-imbalance-and-neuropsychiatric-disorders\/","title":{"rendered":"A 600\u2005kb deletion syndrome at 16p11.2 leads to energy imbalance and neuropsychiatric disorders"},"content":{"rendered":"<p>This paper reports data from large North American and European cohorts that were ascertained for the 16p11.2 deletion (break points 4-5) without regard to age or diagnosis.\u00a0The deletion was previously reported to be among the most frequent known genetic etiologies of autism spectrum disorder and related neurodevelopmental disorders.\u00a0Here the authors describe\u00a0the medical, neuropsychological and behavioral phenotypes in carriers of this deletion compared to intrafamilial non-carrier controls. They report general clinical findings such as head circumference and rates of epilepsy as well as how the deletion impacts IQ, behavior and BMI in a consistent quantitative manner. (By S\u00e9bastien Jacquemont, <a href=\"http:\/\/jmg.bmj.com\/content\/49\/10\/660\">http:\/\/jmg.bmj.com\/content\/49\/10\/660<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This paper reports data from large North American and European cohorts that were ascertained for the 16p11.2 deletion (break points 4-5) without regard to age or diagnosis.\u00a0The deletion was previously reported to be among the most frequent known genetic etiologies of autism spectrum disorder and related neurodevelopmental disorders.\u00a0Here the authors describe\u00a0the medical, neuropsychological and behavioral [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"http:\/\/stg-blogs.bmj.com\/jmg\/2012\/10\/10\/a-600%e2%80%85kb-deletion-syndrome-at-16p11-2-leads-to-energy-imbalance-and-neuropsychiatric-disorders\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-395","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/395","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=395"}],"version-history":[{"count":0,"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/395\/revisions"}],"wp:attachment":[{"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=395"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=395"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/stg-blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=395"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}